Direct thrombin inhibitors.


Journal Article (Review)

Cardiovascular disease is a leading cause of death and pathologic coagulation plays an integral role in the development, propagation, and intervention of cardiovascular disease. The 2 classic anticoagulants, heparin and vitamin K antagonists, though having served humanity for nearly a century, are both inconvenient and nonspecific. Through both direct and indirect roles, thrombin is essential to coagulation, and makes for a very attractive target in medical intervention of pathologic thrombosis. This article will review the nature of direct thrombin inhibitors, current indications, and ongoing trials.

Full Text

Duke Authors

Cited Authors

  • O'Brien, PJ; Mureebe, L

Published Date

  • March 2012

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 5 - 11

PubMed ID

  • 21335484

Pubmed Central ID

  • 21335484

Electronic International Standard Serial Number (EISSN)

  • 1940-4034

Digital Object Identifier (DOI)

  • 10.1177/1074248410395941


  • eng

Conference Location

  • United States