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Current insights on the biology and clinical aspects of VEGF regulation.

Publication ,  Journal Article
Birk, DM; Barbato, J; Mureebe, L; Chaer, RA
Published in: Vasc Endovascular Surg
December 2008

Vascular endothelial growth factor (VEGF) is a key molecule that orchestrates the formation and function of vascular networks. Impaired regulation of angiogenesis is implicated in a number of pathologic states. For instance, neoplasias exhibit uncontrolled angiogenesis, whereas ischemia and states of vascular insufficiency involve reduced VEGF activity. As the role of VEGF has been elucidated in these disease processes, its therapeutic role has been developed. The Food and Drug Administration has approved several anti-VEGF agents for treating colorectal, lung, and kidney cancer. VEGF-inducing agents have also been used experimentally to induce angiogenesis in patients with critical limb ischemia. As more knowledge is gathered about the biology of VEGF and its receptors, there is greater promise for therapeutic modulation of VEGF expression. The purpose of this review is to describe the various therapeutic and biologic factors that regulate the expression of VEGF.

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Published In

Vasc Endovascular Surg

DOI

ISSN

1538-5744

Publication Date

December 2008

Volume

42

Issue

6

Start / End Page

517 / 530

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transcription, Genetic
  • Recombinant Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Oncogenes
  • Neovascularization, Physiologic
  • Neovascularization, Pathologic
  • Neoplasms
  • Ischemia
  • Humans
 

Citation

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Birk, D. M., Barbato, J., Mureebe, L., & Chaer, R. A. (2008). Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovascular Surg, 42(6), 517–530. https://doi.org/10.1177/1538574408322755
Birk, Daniel M., Joel Barbato, Leila Mureebe, and Rabih A. Chaer. “Current insights on the biology and clinical aspects of VEGF regulation.Vasc Endovascular Surg 42, no. 6 (December 2008): 517–30. https://doi.org/10.1177/1538574408322755.
Birk DM, Barbato J, Mureebe L, Chaer RA. Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovascular Surg. 2008 Dec;42(6):517–30.
Birk, Daniel M., et al. “Current insights on the biology and clinical aspects of VEGF regulation.Vasc Endovascular Surg, vol. 42, no. 6, Dec. 2008, pp. 517–30. Pubmed, doi:10.1177/1538574408322755.
Birk DM, Barbato J, Mureebe L, Chaer RA. Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovascular Surg. 2008 Dec;42(6):517–530.
Journal cover image

Published In

Vasc Endovascular Surg

DOI

ISSN

1538-5744

Publication Date

December 2008

Volume

42

Issue

6

Start / End Page

517 / 530

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transcription, Genetic
  • Recombinant Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Oncogenes
  • Neovascularization, Physiologic
  • Neovascularization, Pathologic
  • Neoplasms
  • Ischemia
  • Humans