Platelet function and pharmacologic inhibition.

Journal Article (Journal Article;Review)

Platelets have traditionally been understood within the context of hemostasis and hemorrhagic disorders. However, with increasing procedures being performed in smaller vessels and with an increasing incidence of atherosclerosis, the often critical role platelets play is more evident. Platelets are no longer viewed as "scaffolding" for the events of the coagulation cascade but rather as important catalysts in hemostasis, thrombosis, and fibrinolysis. Improved understanding of platelet physiology has led to developments of pharmacologic adjuncts resulting in improved patency rates and improved patient outcomes. This review addresses the physiology of platelet function and the impact of new pharmacologic agents in percutaneous intervention.

Full Text

Duke Authors

Cited Authors

  • Chaer, RA; Graham, JA; Mureebe, L

Published Date

  • August 2006

Published In

Volume / Issue

  • 40 / 4

Start / End Page

  • 261 - 267

PubMed ID

  • 16959718

International Standard Serial Number (ISSN)

  • 1538-5744

Digital Object Identifier (DOI)

  • 10.1177/1538574406291794


  • eng

Conference Location

  • United States