Hypercoagulable states: a review.

Journal Article (Journal Article;Review)

Vascular surgeons are often asked to evaluate patients with recurrent thromboses or thromboses in unusual locations either arterial or venous. There may be obvious inciting factors, but in many of these patients the possibility of a previously undiagnosed hypercoagulable state must be considered. Hypercoagulable states can be acquired (smoking, medication, change in physiologic status as occurs with pregnancy) or congenital. Congenital hypercoagulable disorders are more prevalent in families or patients with a history of thromboembolic events early in life or multiple miscarriages and include conditions such as protein C or S deficiencies, factor V Leiden mutation, and prothrombin gene variant. This article reviews the hypercoagulable states that are encountered in clinical practice as well as guidelines for testing and goals of therapy.

Full Text

Duke Authors

Cited Authors

  • Johnson, CM; Mureebe, L; Silver, D

Published Date

  • 2005

Published In

Volume / Issue

  • 39 / 2

Start / End Page

  • 123 - 133

PubMed ID

  • 15806273

International Standard Serial Number (ISSN)

  • 1538-5744

Digital Object Identifier (DOI)

  • 10.1177/153857440503900201


  • eng

Conference Location

  • United States