Heparin-induced thrombocytopenia: pathophysiology and management.


Journal Article (Review)

Immune-mediated heparin-induced thrombocytopenia (HIT) is a well-defined syndrome. Clinical criteria (thrombocytopenia, resistance to heparin anticoagulation, or thromboses during heparin therapy) are defined, and serologic diagnostic tests are available. Earlier recognition of HIT syndrome has allowed for significant advances in therapy, leading to marked reductions in morbidity and mortality from HIT syndrome. This review addresses the epidemiology, pathobiology, and management of HIT syndrome

Full Text

Duke Authors

Cited Authors

  • Mureebe, L; Silver, D

Published Date

  • May 2002

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 163 - 170

PubMed ID

  • 12075381

Pubmed Central ID

  • 12075381

Electronic International Standard Serial Number (EISSN)

  • 1938-9116

International Standard Serial Number (ISSN)

  • 1538-5744

Digital Object Identifier (DOI)

  • 10.1177/153857440203600302


  • eng