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Myocardial adenosine triphosphate levels during early sepsis.

Publication ,  Journal Article
Pasque, MK; Murphy, CE; Van Trigt, P; Pellom, GL; Currie, WD; Wechsler, AS
Published in: Arch Surg
December 1983

Myocardial adenosine triphosphate (ATP) levels were determined in rats given sepsis by cecal ligation. Determinations were made after a set time interval, prior to the onset of obtundent effects and immobility, in an attempt to avoid the well-documented, deleterious influence of hypoperfusion status. The absence of a low perfusion state at the time of myocardial biopsy was confirmed by the maintenance of simultaneously determined peripheral organ ATP levels. Myocardial ATP levels were significantly elevated in two groups of septic rats, one minimally hydrated and the other actively hydrated intravenously (IV), when compared with either controls that had not been operated on or animals that underwent sham operations and were IV hydrated. The relationship between elevated myocardial ATP levels and functional status during sepsis deserves further investigation.

Duke Scholars

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

December 1983

Volume

118

Issue

12

Start / End Page

1437 / 1440

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Shock, Septic
  • Rats
  • Myocardium
  • Myocardial Contraction
  • Male
  • Ligation
  • Heart
  • Disease Models, Animal
 

Citation

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Pasque, M. K., Murphy, C. E., Van Trigt, P., Pellom, G. L., Currie, W. D., & Wechsler, A. S. (1983). Myocardial adenosine triphosphate levels during early sepsis. Arch Surg, 118(12), 1437–1440. https://doi.org/10.1001/archsurg.1983.01390120057015
Pasque, M. K., C. E. Murphy, P. Van Trigt, G. L. Pellom, W. D. Currie, and A. S. Wechsler. “Myocardial adenosine triphosphate levels during early sepsis.Arch Surg 118, no. 12 (December 1983): 1437–40. https://doi.org/10.1001/archsurg.1983.01390120057015.
Pasque MK, Murphy CE, Van Trigt P, Pellom GL, Currie WD, Wechsler AS. Myocardial adenosine triphosphate levels during early sepsis. Arch Surg. 1983 Dec;118(12):1437–40.
Pasque, M. K., et al. “Myocardial adenosine triphosphate levels during early sepsis.Arch Surg, vol. 118, no. 12, Dec. 1983, pp. 1437–40. Pubmed, doi:10.1001/archsurg.1983.01390120057015.
Pasque MK, Murphy CE, Van Trigt P, Pellom GL, Currie WD, Wechsler AS. Myocardial adenosine triphosphate levels during early sepsis. Arch Surg. 1983 Dec;118(12):1437–1440.

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

December 1983

Volume

118

Issue

12

Start / End Page

1437 / 1440

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Shock, Septic
  • Rats
  • Myocardium
  • Myocardial Contraction
  • Male
  • Ligation
  • Heart
  • Disease Models, Animal