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Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.

Publication ,  Journal Article
Stern, RS; Väkevä, LH; PUVA Follow-up Study,
Published in: J Invest Dermatol
June 1997

There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we have prospectively followed 1380 patients who first began PUVA treatment for psoriasis in 1975-1976. We compare the risk of noncutaneous cancer in our cohort with that expected based on general population incidence rates. The overall risk of noncutaneous cancer was nearly identical to that expected in general population. For three separate sites, we noted significant increases: thyroid cancer (RR = 3.57, 95% CI = 1.16-8.34), breast cancer (RR = 1.81, 95% CI = 1.19-2.64), and central nervous system neoplasms (RR = 2.80, 95% CI = 1.13-5.57). Since 1987, however, the risk of central nervous system neoplasms has not been elevated (RR = 0.00, 95% CI = 0.00-3.35) and the relative risk of breast cancer was lower than in the prior decade and not statistically significant. There was no association between higher levels of exposure to PUVA and the risk of any of these cancers. We did not detect any significant increase in the risk of lymphoma or leukemia. Our study does not support the hypothesis that long-term PUVA treatment increases the risk of noncutaneous cancer.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1997

Volume

108

Issue

6

Start / End Page

897 / 900

Location

United States

Related Subject Headings

  • Time Factors
  • Thyroid Neoplasms
  • Risk Factors
  • Psoriasis
  • Prospective Studies
  • PUVA Therapy
  • Middle Aged
  • Male
  • Incidence
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Stern, R. S., Väkevä, L. H., & PUVA Follow-up Study, . (1997). Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996. J Invest Dermatol, 108(6), 897–900. https://doi.org/10.1111/1523-1747.ep12292698
Stern, R. S., L. H. Väkevä, and L. H. PUVA Follow-up Study. “Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.J Invest Dermatol 108, no. 6 (June 1997): 897–900. https://doi.org/10.1111/1523-1747.ep12292698.
Stern RS, Väkevä LH, PUVA Follow-up Study. Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996. J Invest Dermatol. 1997 Jun;108(6):897–900.
Stern, R. S., et al. “Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996.J Invest Dermatol, vol. 108, no. 6, June 1997, pp. 897–900. Pubmed, doi:10.1111/1523-1747.ep12292698.
Stern RS, Väkevä LH, PUVA Follow-up Study. Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996. J Invest Dermatol. 1997 Jun;108(6):897–900.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1997

Volume

108

Issue

6

Start / End Page

897 / 900

Location

United States

Related Subject Headings

  • Time Factors
  • Thyroid Neoplasms
  • Risk Factors
  • Psoriasis
  • Prospective Studies
  • PUVA Therapy
  • Middle Aged
  • Male
  • Incidence
  • Humans