Antiinflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. extract.

Published

Journal Article

A study was undertaken to investigate the antiinflammatory efficacy of methanol extract of aerial parts of Barleria lupulina Lindl. [MEBL] (Family: Acanthaceae) in acute and sub-acute inflammation models of albino rats. The MEBL in all the tested dose levels exhibited significant inhibition of carrageenin and serotonin induced paw oedema volumes when compared with the untreated (control) group. The MEBL also exerted a significant reduction in granuloma weight in the cotton pellet induced granuloma model. These potentials were comparable to that of the standard drug (indomethacin). The plant extract was also tested for its analgesic, ulcerogenic and antiperoxidative potential. The extract also demonstrated protection against CCl(4) induced lipid peroxidation and acetic acid induced writhing. Acute administration of MEBL (300 mg/kg) did not produce any gastric lesion in rats.

Full Text

Duke Authors

Cited Authors

  • Suba, V; Murugesan, T; Kumaravelrajan, R; Mandal, SC; Saha, BP

Published Date

  • August 2005

Published In

Volume / Issue

  • 19 / 8

Start / End Page

  • 695 - 699

PubMed ID

  • 16177973

Pubmed Central ID

  • 16177973

Electronic International Standard Serial Number (EISSN)

  • 1099-1573

International Standard Serial Number (ISSN)

  • 0951-418X

Digital Object Identifier (DOI)

  • 10.1002/ptr.1734

Language

  • eng