Antidiarrhoeal activity of Strychnos potatorum seed extract in rats.


Journal Article

The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling.

Full Text

Cited Authors

  • Biswas, S; Murugesan, T; Sinha, S; Maiti, K; Gayen, JR; Pal, M; Saha, BP

Published Date

  • February 2002

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 43 - 47

PubMed ID

  • 11864763

Pubmed Central ID

  • 11864763

Electronic International Standard Serial Number (EISSN)

  • 1873-6971

International Standard Serial Number (ISSN)

  • 0367-326X

Digital Object Identifier (DOI)

  • 10.1016/s0367-326x(01)00368-9


  • eng