Effect of Trichodesma indicum extract on cough reflex induced by sulphur dioxide in mice.


Journal Article (Letter)

The effect of methanol extract of whole plants of Trichodesma indicum R. Br. has been investigated on sulphur dioxide (SO2) induced cough reflex in Swiss albino mice. The extract has demonstrated significant (p < 0.001) inhibition in frequency of cough in all the tested doses when compared with untreated control group. The effect persisted up to 90 min of its oral administration and also comparable to that of the effect exhibited by the standard drug (Codeine phosphate). This study confirmed the traditional use of this plant in the treatment of cough. Determination of underlying mechanism of beneficial effect is major topic requiring further comprehensive investigation.

Full Text

Cited Authors

  • Srikanth, K; Murugesan, T; Kumar, CA; Suba, V; Das, AK; Sinha, S; Arunachalam, G; Manikandan, L

Published Date

  • January 2002

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 75 - 77

PubMed ID

  • 11924768

Pubmed Central ID

  • 11924768

International Standard Serial Number (ISSN)

  • 0944-7113

Digital Object Identifier (DOI)

  • 10.1078/0944-7113-00086


  • eng

Conference Location

  • Germany