Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract.

Published

Journal Article

The methanolic extract of Clerodendrum phlomidis Linn. (MECP) leaves was evaluated for its psychopharmacological activities in several experimental models using Swiss albino mice and Wistar albino rats. The MECP was found to cause significant reduction in spontaneous activity, and decreases in exploratory behavioral profiles by the Y-maze and head dip test. It also showed reduction in muscle relaxant activity by rotarod, 30 degrees inclined screen and traction tests, as well as significantly potentiated the phenobarbitone sodium-induced sleeping time in the doses examined (200, 400 and 600 mg/kg body wt.). All the results were compared with respective controls for the evaluation of significance.

Full Text

Duke Authors

Cited Authors

  • Murugesan, T; Saravanan, KS; Lakshmi, S; Ramya, G; Thenmozhi, K

Published Date

  • November 2001

Published In

Volume / Issue

  • 8 / 6

Start / End Page

  • 472 - 476

PubMed ID

  • 11824524

Pubmed Central ID

  • 11824524

Electronic International Standard Serial Number (EISSN)

  • 1618-095X

International Standard Serial Number (ISSN)

  • 0944-7113

Digital Object Identifier (DOI)

  • 10.1078/s0944-7113(04)70068-9

Language

  • eng