Evaluation of anti-inflammatory potential of Bergenia ciliata Sternb. rhizome extract in rats.

Published

Journal Article

The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for anti-inflammatory potential using two acute rat models (carrageenan- and serotonin (5-HT)-induced rat paw oedema) and a chronic rat model (cotton pouch-induced granuloma). Phenylbutazone (100 mg kg(-1)), a non-steroidal anti-inflammatory agent, was used as a standard. The methanol extract (100, 200 or 300 mg kg(-1)) exhibited significant (P < 0.05) anti-inflammatory activity in all the animal models. At 300 mg kg(-1) the methanol extract exhibited maximum inhibition of 32.4+/-2.89% in carrageenan-induced rat paw oedema while the standard showed an inhibition of 44.1+/-2.7% after 3 h of drug treatment. In the serotonin-induced rat paw oedema model, 300 mg kg(-1) methanol extract suppressed oedema by 45.33+/-2.09%, whereas the standard produced an inhibition of 53.5+/-4.3%. In the cotton pouch granuloma model the methanol extract inhibited significantly (P < 0.001) the granuloma weight in a dose-dependent manner. In this model, 300 mg kg(-1) extract produced a maximum inhibition of 31.4+/-1.09% in granuloma weight compared with 41.1+/-1.32% reduction in granuloma weight for the standard. The methanol extract of B. ciliata exhibited significant anti-inflammatory potential at the dose levels examined.

Full Text

Duke Authors

Cited Authors

  • Sinha, S; Murugesan, T; Maiti, K; Gayen, JR; Pal, M; Saha, BP

Published Date

  • February 2001

Published In

Volume / Issue

  • 53 / 2

Start / End Page

  • 193 - 196

PubMed ID

  • 11273015

Pubmed Central ID

  • 11273015

International Standard Serial Number (ISSN)

  • 0022-3573

Digital Object Identifier (DOI)

  • 10.1211/0022357011775398

Language

  • eng

Conference Location

  • England