Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice.


Journal Article

The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.

Full Text

Cited Authors

  • Sinha, S; Murugesan, T; Pal, M; Saha, BP

Published Date

  • July 2001

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 298 - 301

PubMed ID

  • 11515720

Pubmed Central ID

  • 11515720

International Standard Serial Number (ISSN)

  • 0944-7113

Digital Object Identifier (DOI)

  • 10.1078/0944-7113-00039


  • eng

Conference Location

  • Germany