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Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.

Publication ,  Journal Article
Aubuchon, M; Kunselman, AR; Schlaff, WD; Diamond, MP; Coutifaris, C; Carson, SA; Steinkampf, MP; Carr, BR; McGovern, PG; Cataldo, NA; Myers, ER ...
Published in: J Clin Endocrinol Metab
October 2011

CONTEXT: Nonalcoholic fatty liver disease is common to insulin-resistant states such as polycystic ovary syndrome (PCOS). Metformin (MET) is often used to treat PCOS but information is limited as to its effects on liver function. OBJECTIVE: We sought to determine the effects of MET on serum hepatic parameters in PCOS patients. DESIGN: This was a secondary analysis of a randomized, doubled-blind trial from 2002-2004. SETTING: This multi-center clinical trial was conducted in academic centers. PATIENTS: Six hundred twenty-six infertile women with PCOS with serum liver function parameters less than twice the upper limit of normal were included. INTERVENTIONS: Clomiphene citrate (n = 209), MET (n = 208), or combined (n = 209) were given for up to 6 months. MAIN OUTCOME MEASURE: The percent change from baseline in renal and liver function between- and within-treatment arms was assessed. RESULTS: Renal function improved in all treatment arms with significant decreases in serum blood urea nitrogen levels (range, -14.7 to -21.3%) as well as creatinine (-4.2 to -6.9%). There were similar decreases in liver transaminase levels in the clomiphene citrate and combined arms (-10% in bilirubin, -9 to -11% in transaminases) without significant changes in the MET arm. When categorizing baseline bilirubin, aspartate aminotransferase, and alanine aminotransferase into tertiles, there were significant within-treatment arm differences between the tertiles with the highest tertile having the largest decrease from baseline regardless of treatment arm. CONCLUSION: Women with PCOS can safely use metformin and clomiphene even in the setting of mildly abnormal liver function parameters, and both result in improved renal function.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

October 2011

Volume

96

Issue

10

Start / End Page

E1645 / E1649

Location

United States

Related Subject Headings

  • Polycystic Ovary Syndrome
  • Metformin
  • Liver Function Tests
  • Liver
  • Kidney Function Tests
  • Kidney
  • Infertility, Female
  • Hypoglycemic Agents
  • Humans
  • Fertility Agents, Female
 

Citation

APA
Chicago
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MLA
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Aubuchon, M., Kunselman, A. R., Schlaff, W. D., Diamond, M. P., Coutifaris, C., Carson, S. A., … Reproductive Medicine Network, . (2011). Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome. J Clin Endocrinol Metab, 96(10), E1645–E1649. https://doi.org/10.1210/jc.2011-1093
Aubuchon, Mira, Allen R. Kunselman, William D. Schlaff, Michael P. Diamond, Christos Coutifaris, Sandra A. Carson, Michael P. Steinkampf, et al. “Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.J Clin Endocrinol Metab 96, no. 10 (October 2011): E1645–49. https://doi.org/10.1210/jc.2011-1093.
Aubuchon M, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, et al. Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Oct;96(10):E1645–9.
Aubuchon, Mira, et al. “Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.J Clin Endocrinol Metab, vol. 96, no. 10, Oct. 2011, pp. E1645–49. Pubmed, doi:10.1210/jc.2011-1093.
Aubuchon M, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Legro RS, Reproductive Medicine Network. Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Oct;96(10):E1645–E1649.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

October 2011

Volume

96

Issue

10

Start / End Page

E1645 / E1649

Location

United States

Related Subject Headings

  • Polycystic Ovary Syndrome
  • Metformin
  • Liver Function Tests
  • Liver
  • Kidney Function Tests
  • Kidney
  • Infertility, Female
  • Hypoglycemic Agents
  • Humans
  • Fertility Agents, Female