Rosai-Dorfman disease (extranodal sinus histiocytosis) in a patient with HIV.

Journal Article (Journal Article)

Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytosis of unknown etiology that most commonly involves the cervical lymph nodes. Extranodal involvement occurs in 30-40% of cases, most often in the head and neck. Characteristic histologic findings include emperiopolesis (engulfment) of lymphocytes and S-100 protein positivity. Treatment of Rosai-Dorfman disease is unnecessary unless the disorder becomes life- or organ-threatening, since the disease will resolve spontaneously in most patients. We present what, to the best of our knowledge, is the first reported case of Rosai-Dorfman disease limited to the skin in a patient infected with human immunodeficiency virus. SHML is described and diagnostic and therapeutic measures are reviewed.

Full Text

Duke Authors

Cited Authors

  • Perry, BP; Gregg, CM; Myers, S; Lilly, S; Mann, KP; Prieto, V

Published Date

  • October 1998

Published In

Volume / Issue

  • 77 / 10

Start / End Page

  • 855 - 858

PubMed ID

  • 9818538

International Standard Serial Number (ISSN)

  • 0145-5613


  • eng

Conference Location

  • United States