Skip to main content
Journal cover image

Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.

Publication ,  Journal Article
Medrano, J; Neukam, K; Rallón, N; Rivero, A; Resino, S; Naggie, S; Caruz, A; Calvino, A; Macías, J; Benito, JM; Sánchez-Piedra, C; Vispo, E ...
Published in: Clin Infect Dis
November 15, 2010

BACKGROUND: A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection. Given that therapy is poorly tolerated and rates of response are lower in patients coinfected with HCV and human immunodeficiency virus (HIV), the recognition of predictors of response is a high priority in this population. METHODS: A baseline noninvasive index was derived on the basis of the probability of achieving sustained virological response in a group of 159 HIV-HCV-coinfected patients treated at one clinic in Spain. The index was then validated using data from a separate cohort of 86 coinfected individuals. Only individuals who had completed a course of pegIFN-RBV therapy and had validated outcomes were considered. RESULTS: The final score included 4 variables: 2 host-related variables (IL28B SNP rs12979860 and liver stiffness) and 2 HCV-related variables (genotype and viral load). The area under the receiver operating characteristic curve was 0.89 in the derivation group and 0.85 in the validation group. CONCLUSIONS: The probability of achieving sustained virological response with pegIFN-RBV therapy in HIV-HCV-coinfected patients can be reliably estimated prior to initiation of therapy using an index that includes 4 noninvasive parameters.

Duke Scholars

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

November 15, 2010

Volume

51

Issue

10

Start / End Page

1209 / 1216

Location

United States

Related Subject Headings

  • Viral Load
  • Ribavirin
  • Reproducibility of Results
  • Recombinant Proteins
  • ROC Curve
  • Predictive Value of Tests
  • Polymorphism, Single Nucleotide
  • Polyethylene Glycols
  • Models, Statistical
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Medrano, J., Neukam, K., Rallón, N., Rivero, A., Resino, S., Naggie, S., … Soriano, V. (2010). Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV. Clin Infect Dis, 51(10), 1209–1216. https://doi.org/10.1086/656811
Medrano, Jose, Karin Neukam, Norma Rallón, Antonio Rivero, Salvador Resino, Susanna Naggie, Antonio Caruz, et al. “Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.Clin Infect Dis 51, no. 10 (November 15, 2010): 1209–16. https://doi.org/10.1086/656811.
Medrano J, Neukam K, Rallón N, Rivero A, Resino S, Naggie S, et al. Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV. Clin Infect Dis. 2010 Nov 15;51(10):1209–16.
Medrano, Jose, et al. “Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.Clin Infect Dis, vol. 51, no. 10, Nov. 2010, pp. 1209–16. Pubmed, doi:10.1086/656811.
Medrano J, Neukam K, Rallón N, Rivero A, Resino S, Naggie S, Caruz A, Calvino A, Macías J, Benito JM, Sánchez-Piedra C, Vispo E, Barreiro P, McHutchison J, Pineda JA, Soriano V. Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV. Clin Infect Dis. 2010 Nov 15;51(10):1209–1216.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

November 15, 2010

Volume

51

Issue

10

Start / End Page

1209 / 1216

Location

United States

Related Subject Headings

  • Viral Load
  • Ribavirin
  • Reproducibility of Results
  • Recombinant Proteins
  • ROC Curve
  • Predictive Value of Tests
  • Polymorphism, Single Nucleotide
  • Polyethylene Glycols
  • Models, Statistical
  • Middle Aged