Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA.

Journal Article

We determined estimated incidence of and risk factors for community-associated Clostridium difficile infection (CA-CDI) among patients treated at 6 North Carolina hospitals. CA-CDI case-patients were defined as adults (>18 years of age) with a positive stool test result for C. difficile toxin and no hospitalization within the prior 8 weeks. CA-CDI incidence was 21 and 46 per 100,000 person-years in Veterans Affairs (VA) outpatients and Durham County populations, respectively. VA case-patients were more likely than controls to have received antimicrobial drugs (adjusted odds ratio [aOR] 17.8, 95% confidence interval [CI] 6.6-48] and to have had a recent outpatient visit (aOR 5.1, 95% CI 1.5-17.9). County case-patients were more likely than controls to have received antimicrobial drugs (aOR 9.1, 95% CI 2.9-28.9), to have gastroesophageal reflux disease (aOR 11.2, 95% CI 1.9-64.2), and to have cardiac failure (aOR 3.8, 95% CI 1.1-13.7). Risk factors for CA-CDI overlap with those for healthcare-associated infection.

Full Text

Duke Authors

Cited Authors

  • Kutty, PK; Woods, CW; Sena, AC; Benoit, SR; Naggie, S; Frederick, J; Evans, S; Engel, J; McDonald, LC

Published Date

  • February 2010

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 197 - 204

PubMed ID

  • 20113547

Electronic International Standard Serial Number (EISSN)

  • 1080-6059

Digital Object Identifier (DOI)

  • 10.3201/eid1602.090953

Language

  • eng

Conference Location

  • United States