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RNA-transfected dendritic cells.

Publication ,  Journal Article
Nair, S; Boczkowski, D
Published in: Expert Rev Vaccines
December 2002

Based on their unique ability to stimulate primary immune responses, dendritic cells are the most potent antigen-presenting cells known. This ability stems from the fact that they are very efficient at the uptake and processing of antigen and they express high levels of major histocompatibility complex class I and class II, as well as costimulatory molecules, which are required to prime naive cytotoxic T-cells. Many groups of investigators have tried to take advantage of these features by developing dendritic cell-based vaccines against tumors and infectious diseases. While the basic principle in these studies is the same--dendritic cells pulsed with antigen are used to elicit cytotoxic T-cell responses--the methods used are varied. This is particularly true with respect to the nature of the antigen used and the method of antigen delivery. In this article, we will focus on the use of RNA as a form of antigen with which to load dendritic cells. We will discuss the rationale behind using RNA as an antigen source and will review recent studies in both murine and human settings that use RNA-pulsed dendritic cells as vaccines.

Duke Scholars

Published In

Expert Rev Vaccines

DOI

ISSN

1476-0584

Publication Date

December 2002

Volume

1

Issue

4

Start / End Page

507 / 513

Location

England

Related Subject Headings

  • Virology
  • Transfection
  • RNA
  • Humans
  • Dendritic Cells
  • Clinical Trials as Topic
  • Cancer Vaccines
  • Antigens, Neoplasm
  • Animals
  • 3204 Immunology
 

Citation

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Nair, S., & Boczkowski, D. (2002). RNA-transfected dendritic cells. Expert Rev Vaccines, 1(4), 507–513. https://doi.org/10.1586/14760584.1.4.507
Nair, Smita, and David Boczkowski. “RNA-transfected dendritic cells.Expert Rev Vaccines 1, no. 4 (December 2002): 507–13. https://doi.org/10.1586/14760584.1.4.507.
Nair S, Boczkowski D. RNA-transfected dendritic cells. Expert Rev Vaccines. 2002 Dec;1(4):507–13.
Nair, Smita, and David Boczkowski. “RNA-transfected dendritic cells.Expert Rev Vaccines, vol. 1, no. 4, Dec. 2002, pp. 507–13. Pubmed, doi:10.1586/14760584.1.4.507.
Nair S, Boczkowski D. RNA-transfected dendritic cells. Expert Rev Vaccines. 2002 Dec;1(4):507–513.

Published In

Expert Rev Vaccines

DOI

ISSN

1476-0584

Publication Date

December 2002

Volume

1

Issue

4

Start / End Page

507 / 513

Location

England

Related Subject Headings

  • Virology
  • Transfection
  • RNA
  • Humans
  • Dendritic Cells
  • Clinical Trials as Topic
  • Cancer Vaccines
  • Antigens, Neoplasm
  • Animals
  • 3204 Immunology