Enhanced retention in the passive-avoidance task by 5-HT(1A) receptor blockade is not associated with increased activity of the central nucleus of the amygdala.

Published

Journal Article

The effect of blockade of 5-HT1A receptors was investigated on (1). retention in a mildly aversive passive-avoidance task, and (2). spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of retention. Systemic administration of the selective 5-HT1A antagonist NAN-190 immediately after training markedly-and dose-dependently-facilitated retention in the passive-avoidance task; enhanced retention was time-dependent and was not attributable to variations in wattages of shock received by animals. Systemic administration of NAN-190 had mixed effects on spontaneous single-unit activity of CeA neurons recorded extracellularly in vivo; microiontophoretic application of 5-HT, in contrast, consistently and potently suppressed CeA activity. The present findings-that 5-HT1A receptor blockade by NAN-190 (1). enhances retention in the passive-avoidance task, and (2). does not consistently increase spontaneous neuronal activity of the CeA-provide evidence that a serotonergic system tonically inhibits modulation of retention in the passive-avoidance task through activation of the 5-HT1A receptor subtype at brain sites located outside the CeA.

Full Text

Duke Authors

Cited Authors

  • Schneider, AM; Wilkins, E; Firestone, A; Everbach, EC; Naylor, JC; Simson, PE

Published Date

  • September 2003

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 394 - 400

PubMed ID

  • 14557612

Pubmed Central ID

  • 14557612

International Standard Serial Number (ISSN)

  • 1072-0502

Digital Object Identifier (DOI)

  • 10.1101/lm.54903

Language

  • eng

Conference Location

  • United States