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A combinatorial mechanism for determining the specificity of E2F activation and repression.

Publication ,  Journal Article
Freedman, JA; Chang, JT; Jakoi, L; Nevins, JR
Published in: Oncogene
August 13, 2009

Various studies have detailed the role of E2F proteins in both transcription activation and repression. Further study has shown that distinct promoter elements, but comprising the same E2F-recognition motif, confer positive or negative E2F control and that this reflects binding of either activator or repressor E2F proteins, respectively. We now show that the specificity of binding of an activator or repressor E2F protein is determined by adjacent sequences that bind a cooperating transcription factor. We propose that the functional E2F element is a module comprising not only the E2F-binding site but also the adjacent site for the cooperating transcription factor.

Duke Scholars

Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

August 13, 2009

Volume

28

Issue

32

Start / End Page

2873 / 2881

Location

England

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Response Elements
  • Protein Biosynthesis
  • Protein Binding
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Mutation
  • Humans
 

Citation

APA
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ICMJE
MLA
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Freedman, J. A., Chang, J. T., Jakoi, L., & Nevins, J. R. (2009). A combinatorial mechanism for determining the specificity of E2F activation and repression. Oncogene, 28(32), 2873–2881. https://doi.org/10.1038/onc.2009.153
Freedman, J. A., J. T. Chang, L. Jakoi, and J. R. Nevins. “A combinatorial mechanism for determining the specificity of E2F activation and repression.Oncogene 28, no. 32 (August 13, 2009): 2873–81. https://doi.org/10.1038/onc.2009.153.
Freedman JA, Chang JT, Jakoi L, Nevins JR. A combinatorial mechanism for determining the specificity of E2F activation and repression. Oncogene. 2009 Aug 13;28(32):2873–81.
Freedman, J. A., et al. “A combinatorial mechanism for determining the specificity of E2F activation and repression.Oncogene, vol. 28, no. 32, Aug. 2009, pp. 2873–81. Pubmed, doi:10.1038/onc.2009.153.
Freedman JA, Chang JT, Jakoi L, Nevins JR. A combinatorial mechanism for determining the specificity of E2F activation and repression. Oncogene. 2009 Aug 13;28(32):2873–2881.

Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

August 13, 2009

Volume

28

Issue

32

Start / End Page

2873 / 2881

Location

England

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Response Elements
  • Protein Biosynthesis
  • Protein Binding
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Mutation
  • Humans