Loss of E2F4 activity leads to abnormal development of multiple cellular lineages.

Published

Journal Article

We have generated mice deficient in E2F4 activity, the major form of E2F in many cell types. Analysis of newborn pups deficient in E2F4 revealed abnormalities in hematopoietic lineage development as well as defects in the development of the gut epithelium. Specifically, we observed a deficiency of various mature hematopoietic cell types together with an increased number of immature cells in several lineages. This was associated with an increased frequency of apoptotic cells. We also found a substantial reduction in the thickness of the gut epithelium that normally gives rise to crypts as well as a reduction in the density of villi. These observations suggest a critical role for E2F4 activity in controlling the maturation of cells in a number of tissues.

Full Text

Cited Authors

  • Rempel, RE; Saenz-Robles, MT; Storms, R; Morham, S; Ishida, S; Engel, A; Jakoi, L; Melhem, MF; Pipas, JM; Smith, C; Nevins, JR

Published Date

  • August 2000

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 293 - 306

PubMed ID

  • 10983977

Pubmed Central ID

  • 10983977

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/s1097-2765(00)00030-7

Language

  • eng

Conference Location

  • United States