E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.


Journal Article

The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

Full Text

Cited Authors

  • Nevins, JR

Published Date

  • October 1992

Published In

Volume / Issue

  • 258 / 5081

Start / End Page

  • 424 - 429

PubMed ID

  • 1411535

Pubmed Central ID

  • 1411535

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1411535


  • eng