Interplay between lipids and branched-chain amino acids in development of insulin resistance.

Journal Article (Journal Article;Review)

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.

Full Text

Duke Authors

Cited Authors

  • Newgard, CB

Published Date

  • May 2, 2012

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 606 - 614

PubMed ID

  • 22560213

Pubmed Central ID

  • PMC3695706

Electronic International Standard Serial Number (EISSN)

  • 1932-7420

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2012.01.024


  • eng

Conference Location

  • United States