Getting biological about the genetics of diabetes.

Journal Article (Journal Article)

New technology has provided methods for collecting large amounts of data reflecting gene expression, metabolite and protein abundance, and post-translational modification of proteins. Integration of these various data sets enable the genetic mapping of many new phenotypes and facilitates the creation of network models that link genetic variation with intermediate traits leading to human disease. The first round of genome-wide association studies has not accounted for common human diseases to the extent that was expected. New phenotyping approaches and methods of data integration should bring these studies closer to their promised goals.

Full Text

Duke Authors

Cited Authors

  • Newgard, CB; Attie, AD

Published Date

  • April 2010

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 388 - 391

PubMed ID

  • 20376050

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

Digital Object Identifier (DOI)

  • 10.1038/nm0410-388


  • eng

Conference Location

  • United States