Stochastic facilitation of artificial tactile sensation in primates.

Published

Journal Article

Artificial sensation via electrical or optical stimulation of brain sensory areas offers a promising treatment for sensory deficits. For a brain-machine-brain interface, such artificial sensation conveys feedback signals from a sensorized prosthetic limb. The ways neural tissue can be stimulated to evoke artificial sensation and the parameter space of such stimulation, however, remain largely unexplored. Here we investigated whether stochastic facilitation (SF) could enhance an artificial tactile sensation produced by intracortical microstimulation (ICMS). Two rhesus monkeys learned to use a virtual hand, which they moved with a joystick, to explore virtual objects on a computer screen. They sought an object associated with a particular artificial texture (AT) signaled by a periodic ICMS pattern delivered to the primary somatosensory cortex (S1) through a pair of implanted electrodes. During each behavioral trial, aperiodic ICMS (i.e., noise) of randomly chosen amplitude was delivered to S1 through another electrode pair implanted 1 mm away from the site of AT delivery. Whereas high-amplitude noise worsened AT detection, moderate noise clearly improved the detection of weak signals, significantly raising the proportion of correct trials. These findings suggest that SF could be used to enhance prosthetic sensation.

Full Text

Duke Authors

Cited Authors

  • Medina, LE; Lebedev, MA; O'Doherty, JE; Nicolelis, MAL

Published Date

  • October 10, 2012

Published In

Volume / Issue

  • 32 / 41

Start / End Page

  • 14271 - 14275

PubMed ID

  • 23055496

Pubmed Central ID

  • 23055496

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.3115-12.2012

Language

  • eng

Conference Location

  • United States