Acquiring local field potential information from amperometric neurochemical recordings.

Published

Journal Article

Simultaneous acquisition of in vivo electrophysiological and neurochemical information is essential for understanding how endogenous neurochemicals modulate the dynamics of brain activity. However, up to now such a task has rarely been accomplished due to the major technical challenge of operating two independent recording systems simultaneously in real-time. Here we propose a simpler solution for achieving this goal by using only a standard electrochemical technique--amperometry. To demonstrate its feasibility, we compared amperometric signals with simultaneously recorded local field potential (LFP) signals. We found that the high frequency component (HFC) of the amperometric signals did not reflect neurochemical fluctuations, but instead it resembled LFPs in several aspects, including: (1) coherent spectral fluctuations; (2) clear characterization of different brain states; (3) identical hippocampal theta depth profile. As such, our findings provide the first demonstration that both LFP and local neurochemical information can be simultaneously acquired from electrochemical sensors alone.

Full Text

Duke Authors

Cited Authors

  • Zhang, H; Lin, S-C; Nicolelis, MAL

Published Date

  • May 15, 2009

Published In

Volume / Issue

  • 179 / 2

Start / End Page

  • 191 - 200

PubMed ID

  • 19428527

Pubmed Central ID

  • 19428527

Electronic International Standard Serial Number (EISSN)

  • 1872-678X

Digital Object Identifier (DOI)

  • 10.1016/j.jneumeth.2009.01.023

Language

  • eng

Conference Location

  • Netherlands