Acquiring local field potential information from amperometric neurochemical recordings.
Journal Article (Journal Article)
Simultaneous acquisition of in vivo electrophysiological and neurochemical information is essential for understanding how endogenous neurochemicals modulate the dynamics of brain activity. However, up to now such a task has rarely been accomplished due to the major technical challenge of operating two independent recording systems simultaneously in real-time. Here we propose a simpler solution for achieving this goal by using only a standard electrochemical technique--amperometry. To demonstrate its feasibility, we compared amperometric signals with simultaneously recorded local field potential (LFP) signals. We found that the high frequency component (HFC) of the amperometric signals did not reflect neurochemical fluctuations, but instead it resembled LFPs in several aspects, including: (1) coherent spectral fluctuations; (2) clear characterization of different brain states; (3) identical hippocampal theta depth profile. As such, our findings provide the first demonstration that both LFP and local neurochemical information can be simultaneously acquired from electrochemical sensors alone.
Full Text
Duke Authors
Cited Authors
- Zhang, H; Lin, S-C; Nicolelis, MAL
Published Date
- May 15, 2009
Published In
Volume / Issue
- 179 / 2
Start / End Page
- 191 - 200
PubMed ID
- 19428527
Pubmed Central ID
- PMC2708671
Electronic International Standard Serial Number (EISSN)
- 1872-678X
Digital Object Identifier (DOI)
- 10.1016/j.jneumeth.2009.01.023
Language
- eng
Conference Location
- Netherlands