Primate reaching cued by multichannel spatiotemporal cortical microstimulation.
Journal Article (Journal Article)
Both humans and animals can discriminate signals delivered to sensory areas of their brains using electrical microstimulation. This opens the possibility of creating an artificial sensory channel that could be implemented in neuroprosthetic devices. Although microstimulation delivered through multiple implanted electrodes could be beneficial for this purpose, appropriate microstimulation protocols have not been developed. Here, we report a series of experiments in which owl monkeys performed reaching movements guided by spatiotemporal patterns of cortical microstimulation delivered to primary somatosensory cortex through chronically implanted multielectrode arrays. The monkeys learned to discriminate microstimulation patterns, and their ability to learn new patterns and new behavioral rules improved during several months of testing. Significantly, information was conveyed to the brain through the interplay of microstimulation patterns delivered to multiple electrodes and the temporal order in which these electrodes were stimulated. This suggests multichannel microstimulation as a viable means of sensorizing neural prostheses.
Full Text
Duke Authors
Cited Authors
- Fitzsimmons, NA; Drake, W; Hanson, TL; Lebedev, MA; Nicolelis, MAL
Published Date
- May 23, 2007
Published In
Volume / Issue
- 27 / 21
Start / End Page
- 5593 - 5602
PubMed ID
- 17522304
Pubmed Central ID
- PMC6672750
Electronic International Standard Serial Number (EISSN)
- 1529-2401
Digital Object Identifier (DOI)
- 10.1523/JNEUROSCI.5297-06.2007
Language
- eng
Conference Location
- United States