Combined ultrasonic thermal ablation with interleaved ARFI image monitoring using a single diagnostic curvilinear array: a feasibility study.

Journal Article (Journal Article)

The goal of this work is to demonstrate the feasibility of using a diagnostic ultrasound system (Siemens Antares and CH6-2 curvilinear array) to ablate ex vivo liver with a custom M-mode sequence and monitor the resulting tissue stiffening with 2-D Acoustic Radiation Force Impulse (ARFI) imaging. Images were taken before and after ablation, as well as in 5- s intervals during the ablation sequence in order to monitor the ablation lesion formation temporally. Ablation lesions were generated at depths up to 1.5 cm from the surface of the liver and were not visible in B-mode. ARFI images showed liver stiffening with heating that corresponded to discolored regions in gross pathology. As expected, the contrast of ablation lesions in ARFI images is observed to increase with ablation lesion size. This study demonstrated the ability of a diagnostic system using custom beam sequences to localize an ablation site, heat the site to the point of irreversible damage and monitor the formation of the ablation lesion with ARFI imaging.

Full Text

Duke Authors

Cited Authors

  • Bing, KF; Rouze, NC; Palmeri, ML; Rotemberg, VM; Nightingale, KR

Published Date

  • October 2011

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 217 - 232

PubMed ID

  • 22518953

Pubmed Central ID

  • PMC3334871

Electronic International Standard Serial Number (EISSN)

  • 1096-0910

International Standard Serial Number (ISSN)

  • 0161-7346

Digital Object Identifier (DOI)

  • 10.1177/016173461103300402


  • eng