Strain theory of malaria: the first 50 years.


Journal Article (Review)

From the 1920s to the 1970s, a large body of principles and evidence accumulated about the existence and character of 'strains' among the Plasmodium species responsible for human malaria. An extensive research literature examined the degree to which strains were autonomous, stable biological entities, distinguishable by clinical, epidemiological or other features, and how this knowledge could be used to benefit medical and public health practice. Strain theory in this era was based largely on parasite phenotypes related to clinical virulence, reactions to anti-malarial drugs, infectivity to mosquitoes, antigenic properties and host immunity, latency and relapse. Here we review the search for a definition of 'strain', suggest how the data and discussion shaped current understandings of many aspects of malaria and sketch a number of specific connections with perspectives from the past 30 years.

Full Text

Duke Authors

Cited Authors

  • McKenzie, FE; Smith, DL; O'Meara, WP; Riley, EM

Published Date

  • 2008

Published In

Volume / Issue

  • 66 /

Start / End Page

  • 1 - 46

PubMed ID

  • 18486688

Pubmed Central ID

  • 18486688

International Standard Serial Number (ISSN)

  • 0065-308X

Digital Object Identifier (DOI)

  • 10.1016/S0065-308X(08)00201-7


  • eng

Conference Location

  • England