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Peptides from conus venoms which affect ca+plus; entry into neurons

Publication ,  Journal Article
Myers, RA; Mcintosh, JM; Imperial, J; Williams, RW; Oas, T; Haack, JA; Hernandez, JF; Rivier, J; Cruz, LJ; Olivera, BM
Published in: Toxin Reviews
January 1, 1990

The venoms of fish-hunting Conus contain paralytic conotoxins and an unprecedented variety of other biologically-active peptides. Particularly noteworthy are peptides which inhibit calcium entry into neurons, the conantokins and w-conotoxins which target NMDA receptors and voltage-sensitive Ca channels respectively. The conantokins contain at least four residues of γcarboxyglutamate (Gla), a post-translationally modified amino acid. Conantokins are folded into an αhelical conformation and bind acidic membranes in a calcium-dependent manner. Upon envenomation, conantokins may concentrate on appropriate membranes and target to peripheral fish NMDA receptors located on such membranes. The w-conotoxins are disulfide bonded peptides; a comparison of several w-conotoxin sequences reveals considerable sequence variability. Recent studies with w-conotoxins have also revealed a developmental specificity in mice. The results suggest that elements controlling breathing in neonatal mammals, but not in adults, are w-conotoxin sensitive. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Duke Scholars

Published In

Toxin Reviews

DOI

ISSN

1556-9543

Publication Date

January 1, 1990

Volume

9

Issue

2

Start / End Page

179 / 202

Related Subject Headings

  • Toxicology
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Myers, R. A., Mcintosh, J. M., Imperial, J., Williams, R. W., Oas, T., Haack, J. A., … Olivera, B. M. (1990). Peptides from conus venoms which affect ca+plus; entry into neurons. Toxin Reviews, 9(2), 179–202. https://doi.org/10.3109/15569549009033113
Myers, R. A., J. M. Mcintosh, J. Imperial, R. W. Williams, T. Oas, J. A. Haack, J. F. Hernandez, J. Rivier, L. J. Cruz, and B. M. Olivera. “Peptides from conus venoms which affect ca+plus; entry into neurons.” Toxin Reviews 9, no. 2 (January 1, 1990): 179–202. https://doi.org/10.3109/15569549009033113.
Myers RA, Mcintosh JM, Imperial J, Williams RW, Oas T, Haack JA, et al. Peptides from conus venoms which affect ca+plus; entry into neurons. Toxin Reviews. 1990 Jan 1;9(2):179–202.
Myers, R. A., et al. “Peptides from conus venoms which affect ca+plus; entry into neurons.” Toxin Reviews, vol. 9, no. 2, Jan. 1990, pp. 179–202. Scopus, doi:10.3109/15569549009033113.
Myers RA, Mcintosh JM, Imperial J, Williams RW, Oas T, Haack JA, Hernandez JF, Rivier J, Cruz LJ, Olivera BM. Peptides from conus venoms which affect ca+plus; entry into neurons. Toxin Reviews. 1990 Jan 1;9(2):179–202.

Published In

Toxin Reviews

DOI

ISSN

1556-9543

Publication Date

January 1, 1990

Volume

9

Issue

2

Start / End Page

179 / 202

Related Subject Headings

  • Toxicology
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences