The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery.

Journal Article (Journal Article)

The TCT motif (polypyrimidine initiator) encompasses the transcription start site of nearly all ribosomal protein genes in Drosophila and mammals. The TCT motif is required for transcription of ribosomal protein gene promoters. The TCT element resembles the Inr (initiator), but is not recognized by TFIID and cannot function in lieu of an Inr. However, a single T-to-A substitution converts the TCT element into a functionally active Inr. Thus, the TCT motif is a novel transcriptional element that is distinct from the Inr. These findings reveal a specialized TCT-based transcription system that is directed toward the synthesis of ribosomal proteins.

Full Text

Duke Authors

Cited Authors

  • Parry, TJ; Theisen, JWM; Hsu, J-Y; Wang, Y-L; Corcoran, DL; Eustice, M; Ohler, U; Kadonaga, JT

Published Date

  • September 15, 2010

Published In

Volume / Issue

  • 24 / 18

Start / End Page

  • 2013 - 2018

PubMed ID

  • 20801935

Pubmed Central ID

  • PMC2939363

Electronic International Standard Serial Number (EISSN)

  • 1549-5477

Digital Object Identifier (DOI)

  • 10.1101/gad.1951110


  • eng

Conference Location

  • United States