Bivalirudin: a review of the pharmacology and clinical application.

Published

Journal Article (Review)

Among the current agents in the class of direct thrombin inhibitors, bivalirudin (Angiomax(®), The Medicines Company, NJ, USA) has seen increased use in cardiovascular medicine over the past decade through its primary indication as an anticoagulant used during percutaneous coronary interventions. Bivalirudin has been further investigated and used as the anticoagulation strategy in the setting of cardiac and endovascular surgical procedures and is frequently utilized in the management of patients with heparin-induced thrombocytopenia. In comparison with heparin, bivalirudin exhibits a low immunogenic profile and provides similar or reduced major bleeding rates as well as a predictable degree of anticoagulation that is dose related. Bivalirudin primarily undergoes dual elimination via proteolytic cleavage and renal elimination, and requires dose adjustment in the setting of severe renal dysfunction. Given the body of supportive data, bivalirudin is likely to continue to figure prominently as a reliable and efficient anticoagulation strategy. Additional agents in the class of direct thrombin inhibitors are under investigation and may find increasing clinical use.

Full Text

Duke Authors

Cited Authors

  • Van De Car, DA; Rao, SV; Ohman, EM

Published Date

  • December 2010

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 1673 - 1681

PubMed ID

  • 21108549

Pubmed Central ID

  • 21108549

Electronic International Standard Serial Number (EISSN)

  • 1744-8344

International Standard Serial Number (ISSN)

  • 1477-9072

Digital Object Identifier (DOI)

  • 10.1586/erc.10.158

Language

  • eng