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Risk factor profile and management of cerebrovascular patients in the REACH Registry.

Publication ,  Journal Article
Röther, J; Alberts, MJ; Touzé, E; Mas, J-L; Hill, MD; Michel, P; Bhatt, DL; Aichner, FT; Goto, S; Matsumoto, M; Ohman, EM; Okada, Y; Steg, PG ...
Published in: Cerebrovasc Dis
2008

BACKGROUND: Cerebrovascular disease (CVD) is a global public health problem. CVD patients are at high risk of recurrent stroke and other atherothrombotic events. Prevalence of risk factors, comorbidities, utilization of secondary prevention therapies and adherence to guidelines all influence the recurrent event rate. We assessed these factors in 18,992 CVD patients within a worldwide registry of stable outpatients. METHODS: The Reduction of Atherothrombosis for Continued Health Registry recruited >68,000 outpatients (44 countries). The subjects were mainly recruited by general practitioners (44%) and internists (29%) if they had symptomatic CVD, coronary artery disease, peripheral arterial disease (PAD) and/or >or=3 atherothrombotic risk factors. RESULTS: The 18,992 CVD patients suffered a stroke (53.7%), transient ischemic attack (TIA) (27.7%) or both (18.5%); 40% had symptomatic atherothrombotic disease in >or=1 additional vascular beds: 36% coronary artery disease; 10% PAD and 6% both. The prevalence of risk factors at baseline was higher in the TIA subgroup than in the stroke group: treated hypertension (83.5/82.0%; p = 0.02), body mass index >or=30 (26.7/20.8%; p < 0.0001), hypercholesterolemia (65.1/52.1%; p < 0.0001), atrial fibrillation (14.7/11.9%; p < 0.0001) and carotid artery disease (42.3/29.7%; p < 0.0001). CVD patients received antiplatelet agents (81.7%), oral anticoagulants (17.3%), lipid-lowering agents (61.2%) and antihypertensives (87.9%), but guideline treatment targets were frequently not achieved (54.5% had elevated blood pressure at baseline, while 4.5% had untreated diabetes). CONCLUSIONS: A high percentage of CVD patients have additional atherothrombotic disease manifestations. The risk profile puts CVD patients, especially the TIA subgroup, at high risk for future atherothrombotic events. Undertreatment is common worldwide and adherence to guidelines needs to be enforced.

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Published In

Cerebrovasc Dis

DOI

EISSN

1421-9786

Publication Date

2008

Volume

25

Issue

4

Start / End Page

366 / 374

Location

Switzerland

Related Subject Headings

  • Stroke
  • Secondary Prevention
  • Risk Factors
  • Registries
  • Prospective Studies
  • Prevalence
  • Platelet Aggregation Inhibitors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
 

Citation

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ICMJE
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Röther, J., Alberts, M. J., Touzé, E., Mas, J.-L., Hill, M. D., Michel, P., … REACH Registry Investigators, . (2008). Risk factor profile and management of cerebrovascular patients in the REACH Registry. Cerebrovasc Dis, 25(4), 366–374. https://doi.org/10.1159/000120687
Röther, Joachim, Mark J. Alberts, Emmanuel Touzé, Jean-Louis Mas, Michael D. Hill, Patrik Michel, Deepak L. Bhatt, et al. “Risk factor profile and management of cerebrovascular patients in the REACH Registry.Cerebrovasc Dis 25, no. 4 (2008): 366–74. https://doi.org/10.1159/000120687.
Röther J, Alberts MJ, Touzé E, Mas J-L, Hill MD, Michel P, et al. Risk factor profile and management of cerebrovascular patients in the REACH Registry. Cerebrovasc Dis. 2008;25(4):366–74.
Röther, Joachim, et al. “Risk factor profile and management of cerebrovascular patients in the REACH Registry.Cerebrovasc Dis, vol. 25, no. 4, 2008, pp. 366–74. Pubmed, doi:10.1159/000120687.
Röther J, Alberts MJ, Touzé E, Mas J-L, Hill MD, Michel P, Bhatt DL, Aichner FT, Goto S, Matsumoto M, Ohman EM, Okada Y, Uchiyama S, D’Agostino R, Hirsch AT, Wilson PWF, Steg PG, REACH Registry Investigators. Risk factor profile and management of cerebrovascular patients in the REACH Registry. Cerebrovasc Dis. 2008;25(4):366–374.
Journal cover image

Published In

Cerebrovasc Dis

DOI

EISSN

1421-9786

Publication Date

2008

Volume

25

Issue

4

Start / End Page

366 / 374

Location

Switzerland

Related Subject Headings

  • Stroke
  • Secondary Prevention
  • Risk Factors
  • Registries
  • Prospective Studies
  • Prevalence
  • Platelet Aggregation Inhibitors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male