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β-adrenoceptor adaptation to endurance training

Publication ,  Journal Article
Ohman, EM; Butler, J; Kelly, J; Horgan, J; O’Malley, K
Published in: Journal of Cardiovascular Pharmacology
January 1, 1987

Endurance exercise is associated with various cardiovascular adaptations, and these may include changes in sympathoadrenal activity and end-organ responsiveness to norepinephrine (NE). Because (3-adreno-ceptor function is a major determinant of sympathetic responsiveness, we used the lymphocyte p-adrenoceptoras a model to study the effects of endurance training in 19 male subjects before, during, and after preparation for a marathon race. Before the subjects trained, resting βadrenoceptor density was positively correlated to resting heart rate (r = 0.47, p < 0.05) but this correlation was not evident after training. Eleven of the 19 subjects completed the 31/2-month training period, and mean (±1 SD) resting p-adrenoceptor density fell from 1,593 ± 333 to 1,197 ± 332 sites per cell (p < 0.02) after the training period. Two weeks after cessation of training, receptor density was at pretraining values of 1,547 ± 209 sites per cell. During training, the subjects ran two 21-km races. Each of these was associated with decreases in β-adrenoceptor density. Our results demonstrate the episodes of endurance running result in reductions in lymphocyte p-adrenoceptor density. We conclude that down-regulation of p-adrenoceptors is an important component of the response to endurance training. © 1987 Raven Press, Ltd., New York.

Duke Scholars

Published In

Journal of Cardiovascular Pharmacology

DOI

EISSN

1533-4023

ISSN

0160-2446

Publication Date

January 1, 1987

Volume

10

Issue

6

Start / End Page

728 / 731

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Ohman, E. M., Butler, J., Kelly, J., Horgan, J., & O’Malley, K. (1987). β-adrenoceptor adaptation to endurance training. Journal of Cardiovascular Pharmacology, 10(6), 728–731. https://doi.org/10.1097/00005344-198712000-00018
Ohman, E. M., J. Butler, J. Kelly, J. Horgan, and K. O’Malley. “β-adrenoceptor adaptation to endurance training.” Journal of Cardiovascular Pharmacology 10, no. 6 (January 1, 1987): 728–31. https://doi.org/10.1097/00005344-198712000-00018.
Ohman EM, Butler J, Kelly J, Horgan J, O’Malley K. β-adrenoceptor adaptation to endurance training. Journal of Cardiovascular Pharmacology. 1987 Jan 1;10(6):728–31.
Ohman, E. M., et al. “β-adrenoceptor adaptation to endurance training.” Journal of Cardiovascular Pharmacology, vol. 10, no. 6, Jan. 1987, pp. 728–31. Scopus, doi:10.1097/00005344-198712000-00018.
Ohman EM, Butler J, Kelly J, Horgan J, O’Malley K. β-adrenoceptor adaptation to endurance training. Journal of Cardiovascular Pharmacology. 1987 Jan 1;10(6):728–731.

Published In

Journal of Cardiovascular Pharmacology

DOI

EISSN

1533-4023

ISSN

0160-2446

Publication Date

January 1, 1987

Volume

10

Issue

6

Start / End Page

728 / 731

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3214 Pharmacology and pharmaceutical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology