Review of the treatment of mycosis fungoides and sézary syndrome: a stage-based approach.

Journal Article (Journal Article;Review)

The NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin's Disease were recently revised to include recommendations for treating mycosis fungoides and Sézary syndrome. These uncommon lymphomas require a specialized evaluation and use a unique TNMB staging system. Unlike the other forms of non-Hodgkin's lymphomas, stage overwhelmingly determines prognosis and defines radically different treatment approaches. For patients with early-stage disease, initial treatment with skin-directed therapies is preferred, and many patients never require systemic therapy. For patients with refractory or advanced-stage disease, biologic therapies are often the first choices, whereas chemotherapies are reserved for later in the disease course. Many milder therapies may be repeated several times in the disease course, and maintenance and tapering strategies are common. This article also discusses the emerging role of allogeneic stem cell transplantation.

Full Text

Duke Authors

Cited Authors

  • Horwitz, SM; Olsen, EA; Duvic, M; Porcu, P; Kim, YH

Published Date

  • April 2008

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 436 - 442

PubMed ID

  • 18433609

International Standard Serial Number (ISSN)

  • 1540-1405

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2008.0033


  • eng

Conference Location

  • United States