Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

A 24-month double-blind, randomized, placebo-controlled, parallel-group, multicenter study of 424 men was conducted to determine the efficacy and tolerability of finasteride 1 mg on hair growth/loss in men aged 41 to 60 years with mild-to-moderate, predominantly vertex male pattern hair loss. Efficacy was evaluated by review of global photographs of the vertex scalp taken at baseline and at Months 6, 12, 18, and 24 and by patient self-assessments and investigator clinical assessments of change from baseline in hair growth/loss collected at Months 6, 12, 18, and 24. Safety analyses included assessment of clinical and laboratory adverse experiences, including sexual adverse experiences. Analysis of global photographic assessment data showed significant improvement in hair growth for men in the finasteride group compared with those taking placebo beginning at Month 6 (p < 0.001) and maintained through Month 24 (p < 0.001). Results of the patient self-assessment and investigator assessments were consistent with those from the global photographic assessment. Finasteride 1 mg improved scalp hair growth in men aged 41 to 60 years with predominantly vertex male pattern hair loss compared with results seen with placebo. Improvement was evident by 6 months of treatment and continued through 24 months. Treatment with finasteride 1 mg was generally well tolerated.

Full Text

Duke Authors

Cited Authors

  • Whiting, DA; Olsen, EA; Savin, R; Halper, L; Rodgers, A; Wang, L; Hustad, C; Palmisano, J; Male Pattern Hair Loss Study Group,

Published Date

  • March 2003

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 150 - 160

PubMed ID

  • 12695131

Pubmed Central ID

  • 12695131

International Standard Serial Number (ISSN)

  • 1167-1122


  • eng

Conference Location

  • France