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Interferon in the treatment of cutaneous T-cell lymphoma.

Publication ,  Journal Article
Olsen, EA
Published in: Dermatol Ther
2003

Interferons are polypeptides with a broad range of in vivo effects that have shown efficacy in cutaneous T-cell lymphoma (CTCL). Particularly useful is alfa interferon (IFN) which, as a single agent, has shown partial remission rates of > 50% and complete responses of > 20%. Side-effects are predictable, generally well tolerated and dose-related. The efficacy of IFN has increased with combination therapy without any significant increase in attendant side-effects. An update on the specifics of the different IFN subtypes, their inherent biologic activity, pharmacokinetics, efficacy and safety in CTCL is presented in this paper.

Duke Scholars

Published In

Dermatol Ther

DOI

ISSN

1396-0296

Publication Date

2003

Volume

16

Issue

4

Start / End Page

311 / 321

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Skin Neoplasms
  • Risk Assessment
  • Recombinant Proteins
  • Prognosis
  • Neoplasm Staging
  • Mycosis Fungoides
  • Male
  • Lymphoma, T-Cell, Cutaneous
 

Citation

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Olsen, E. A. (2003). Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther, 16(4), 311–321. https://doi.org/10.1111/j.1396-0296.2003.01643.x
Olsen, Elise A. “Interferon in the treatment of cutaneous T-cell lymphoma.Dermatol Ther 16, no. 4 (2003): 311–21. https://doi.org/10.1111/j.1396-0296.2003.01643.x.
Olsen EA. Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther. 2003;16(4):311–21.
Olsen, Elise A. “Interferon in the treatment of cutaneous T-cell lymphoma.Dermatol Ther, vol. 16, no. 4, 2003, pp. 311–21. Pubmed, doi:10.1111/j.1396-0296.2003.01643.x.
Olsen EA. Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther. 2003;16(4):311–321.
Journal cover image

Published In

Dermatol Ther

DOI

ISSN

1396-0296

Publication Date

2003

Volume

16

Issue

4

Start / End Page

311 / 321

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Skin Neoplasms
  • Risk Assessment
  • Recombinant Proteins
  • Prognosis
  • Neoplasm Staging
  • Mycosis Fungoides
  • Male
  • Lymphoma, T-Cell, Cutaneous