Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

BACKGROUND: The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously. OBJECTIVE: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use. METHODS: Photodamaged subjects who completed 24 weeks of once-daily use of tretinoin emollient cream 0.05% (n = 149) or 0.01% (n = 149) continued to use the same strength formulation in a 24-week double-blind extension. RESULTS: Maintenance of improvement or continued reduction in signs of photodamage was noted in both investigators' and subjects' evaluations of the 0.05% and 0.01% preparations; these results were confirmed by skin replica analyses. Cutaneous side effects were less common during the extension study than during the first 24 weeks of therapy. CONCLUSION: Both strengths of tretinoin emollient cream (0.05% and 0.01%) appeared safe and effective in the treatment of photodamaged skin during a 48-week treatment period.

Full Text

Duke Authors

Cited Authors

  • Olsen, EA; Katz, HI; Levine, N; Nigra, TP; Pochi, PE; Savin, RC; Shupack, J; Weinstein, GD; Lufrano, L; Perry, BH

Published Date

  • August 1997

Published In

Volume / Issue

  • 37 / 2 Pt 1

Start / End Page

  • 217 - 226

PubMed ID

  • 9270507

International Standard Serial Number (ISSN)

  • 0190-9622

Digital Object Identifier (DOI)

  • 10.1016/s0190-9622(97)80128-4


  • eng

Conference Location

  • United States