Histologic evaluation of the long term effects of tretinoin on photodamaged skin.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

Sustained improvement with prolonged topical tretinoin for photodamaged skin has been well documented for up to 22 months of continuous treatment. We now report long-term (4 years) histologic effects of topical tretinoin in photodamaged skin of 27 patients, the longest study to date. The observed decreases in dermal elastin content and perivascular inflammation and increase in epidermal mucin in facial biopsies obtained after up to 4 years of treatment may be partly responsible for the continued clinical improvement. Furthermore, the study shows that there are no untoward effects on keratinocytes or melanocytes during long-term use of topical tretinoin.

Full Text

Duke Authors

Cited Authors

  • Bhawan, J; Olsen, E; Lufrano, L; Thorne, EG; Schwab, B; Gilchrest, BA

Published Date

  • March 1996

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 177 - 182

PubMed ID

  • 8785167

International Standard Serial Number (ISSN)

  • 0923-1811

Digital Object Identifier (DOI)

  • 10.1016/0923-1811(95)00432-7


  • eng

Conference Location

  • Netherlands