Histologic evaluation of the long term effects of tretinoin on photodamaged skin.
Journal Article (Clinical Trial;Journal Article;Multicenter Study)
Sustained improvement with prolonged topical tretinoin for photodamaged skin has been well documented for up to 22 months of continuous treatment. We now report long-term (4 years) histologic effects of topical tretinoin in photodamaged skin of 27 patients, the longest study to date. The observed decreases in dermal elastin content and perivascular inflammation and increase in epidermal mucin in facial biopsies obtained after up to 4 years of treatment may be partly responsible for the continued clinical improvement. Furthermore, the study shows that there are no untoward effects on keratinocytes or melanocytes during long-term use of topical tretinoin.
Full Text
Duke Authors
Cited Authors
- Bhawan, J; Olsen, E; Lufrano, L; Thorne, EG; Schwab, B; Gilchrest, BA
Published Date
- March 1996
Published In
Volume / Issue
- 11 / 3
Start / End Page
- 177 - 182
PubMed ID
- 8785167
International Standard Serial Number (ISSN)
- 0923-1811
Digital Object Identifier (DOI)
- 10.1016/0923-1811(95)00432-7
Language
- eng
Conference Location
- Netherlands