Human test models for bioequivalence of topical corticosteroids: a review.

Published

Journal Article (Review)

It would be useful to have a safe, reliable, reproducible, and inexpensive human test model to determine the potency of topical corticosteroids and the bioequivalence of generic agents. Existing human test systems include erythema or inflammation induced by irritants or other stimuli, experimentally induced cutaneous disease-like states, and bioassays in patients with psoriasis. None of these systems is currently reliable enough to warrant general use. Among the shortcomings of existing test systems are the difficulty of producing a uniform, steroid-responsive test condition, the requirement to use occlusion in several of the systems, and the lack of agreement among the results of different tests. Despite these shortcomings, some of the tests may prove useful in comparing innovator and generic topical corticosteroids and in screening the potency of new agents.

Full Text

Duke Authors

Cited Authors

  • Olsen, EA

Published Date

  • October 1992

Published In

Volume / Issue

  • 31 Suppl 1 /

Start / End Page

  • 9 - 13

PubMed ID

  • 1428469

Pubmed Central ID

  • 1428469

International Standard Serial Number (ISSN)

  • 0011-9059

Digital Object Identifier (DOI)

  • 10.1111/j.1365-4362.1992.tb04006.x

Language

  • eng

Conference Location

  • England