A double-blind controlled comparison of generic and trade-name topical steroids using the vasoconstriction assay.

Journal Article (Clinical Trial;Journal Article)

Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay.

Full Text

Duke Authors

Cited Authors

  • Olsen, EA

Published Date

  • February 1991

Published In

Volume / Issue

  • 127 / 2

Start / End Page

  • 197 - 201

PubMed ID

  • 1990984

International Standard Serial Number (ISSN)

  • 0003-987X


  • eng

Conference Location

  • United States