The pharmacology of methotrexate.

Journal Article (Review;Journal Article)

Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.

Full Text

Duke Authors

Cited Authors

  • Olsen, EA

Published Date

  • August 1991

Published In

Volume / Issue

  • 25 / 2 Pt 1

Start / End Page

  • 306 - 318

PubMed ID

  • 1918470

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

International Standard Serial Number (ISSN)

  • 0190-9622

Digital Object Identifier (DOI)

  • 10.1016/0190-9622(91)70199-c


  • eng