The pharmacology of methotrexate.

Journal Article (Review;Journal Article)

Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Olsen, Elise Arline

Cited Authors

Olsen, EA

Published Date

August 1991

Published In

Journal of the American Academy of Dermatology

Volume / Issue

25 / 2 Pt 1

Start / End Page

306 - 318

PubMed ID

1918470

Electronic International Standard Serial Number (EISSN)

1097-6787

International Standard Serial Number (ISSN)

0190-9622

Digital Object Identifier (DOI)

10.1016/0190-9622(91)70199-c

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