The pharmacology of methotrexate.
Published
Journal Article (Review)
Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.
Full Text
Duke Authors
Cited Authors
- Olsen, EA
Published Date
- August 1991
Published In
Volume / Issue
- 25 / 2 Pt 1
Start / End Page
- 306 - 318
PubMed ID
- 1918470
Pubmed Central ID
- 1918470
International Standard Serial Number (ISSN)
- 0190-9622
Digital Object Identifier (DOI)
- 10.1016/0190-9622(91)70199-c
Language
- eng
Conference Location
- United States