A double-blind, placebo-controlled trial of acitretin for the treatment of psoriasis.

Published

Journal Article

Acitretin, the active metabolite of etretinate, has the clinical advantage of a much shorter terminal elimination half-life. We report the results of a double-blind, placebo-controlled trial of acitretin (Soriatane) in 15 patients with moderate to severe psoriasis. Patients received 25 mg or 50 mg daily of acitretin or placebo in a double-blind fashion for 8 weeks and then were given 25 to 75 mg acitretin daily during an open study. Only two placebo patients completed the double-blind phase; one patient's psoriasis worsened, and one showed no significant change. All 15 patients then completed at least 8 weeks with 25 to 75 mg acitretin daily, with a moderate change in erythema, scaling, and induration (mean 28% to 37% improvement) but with minimal change in the percentage of body surface area involved. Prolonged treatment (greater than or equal to 20 weeks) with acitretin resulted in further significant improvement and a 44% reduction of involved surface area from baseline.

Full Text

Duke Authors

Cited Authors

  • Olsen, EA; Weed, WW; Meyer, CJ; Cobo, LM

Published Date

  • October 1989

Published In

Volume / Issue

  • 21 / 4 Pt 1

Start / End Page

  • 681 - 686

Pubmed Central ID

  • 2530251

Electronic International Standard Serial Number (EISSN)

  • 1097-6787

International Standard Serial Number (ISSN)

  • 0190-9622

Digital Object Identifier (DOI)

  • 10.1016/s0190-9622(89)70236-x

Language

  • eng