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Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

Publication ,  Journal Article
Ong, ST; Hackbarth, ML; Degenstein, LC; Baunoch, DA; Anastasi, J; McKeithan, TW
Published in: Oncogene
May 7, 1998

The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the role of BCL3 overexpression in lymphoid malignancies, we generated five lines of E mu-BCL3 transgenic mice. Transgenic animals develop normally but show splenomegaly and an accumulation of mature B cells in lymph nodes, bone marrow and peritoneal cavity. A hyperresponsive immune system is suggested by the follicular hyperplasia and plasmacytosis in lymph nodes of unimmunized animals, increased incidence of antibodies to self-antigens, and a heightened response to cross-linking of surface IgM. Statistically significant decreases in serum IgM and IgG3, but an increase in IgG1 and IgA were also observed. No lymphoid neoplasms have been identified in transgenic animals. The expansion of B cells in vivo is consistent with the overexpression of BCL3 as being one step in the multi-step process of leukemogenesis. The phenotype also suggests that BCL3 plays a part in B cell proliferation and isotype switching.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

May 7, 1998

Volume

16

Issue

18

Start / End Page

2333 / 2343

Location

England

Related Subject Headings

  • Transcription Factors
  • Splenomegaly
  • Spleen
  • Proto-Oncogene Proteins c-bcr
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Oncogene Proteins
  • NF-kappa B
  • Mice, Transgenic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ong, S. T., Hackbarth, M. L., Degenstein, L. C., Baunoch, D. A., Anastasi, J., & McKeithan, T. W. (1998). Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. Oncogene, 16(18), 2333–2343. https://doi.org/10.1038/sj.onc.1201771
Ong, S. T., M. L. Hackbarth, L. C. Degenstein, D. A. Baunoch, J. Anastasi, and T. W. McKeithan. “Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.Oncogene 16, no. 18 (May 7, 1998): 2333–43. https://doi.org/10.1038/sj.onc.1201771.
Ong ST, Hackbarth ML, Degenstein LC, Baunoch DA, Anastasi J, McKeithan TW. Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. Oncogene. 1998 May 7;16(18):2333–43.
Ong, S. T., et al. “Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.Oncogene, vol. 16, no. 18, May 1998, pp. 2333–43. Pubmed, doi:10.1038/sj.onc.1201771.
Ong ST, Hackbarth ML, Degenstein LC, Baunoch DA, Anastasi J, McKeithan TW. Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. Oncogene. 1998 May 7;16(18):2333–2343.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

May 7, 1998

Volume

16

Issue

18

Start / End Page

2333 / 2343

Location

England

Related Subject Headings

  • Transcription Factors
  • Splenomegaly
  • Spleen
  • Proto-Oncogene Proteins c-bcr
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • Oncology & Carcinogenesis
  • Oncogene Proteins
  • NF-kappa B
  • Mice, Transgenic