Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

Published

Journal Article

The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the role of BCL3 overexpression in lymphoid malignancies, we generated five lines of E mu-BCL3 transgenic mice. Transgenic animals develop normally but show splenomegaly and an accumulation of mature B cells in lymph nodes, bone marrow and peritoneal cavity. A hyperresponsive immune system is suggested by the follicular hyperplasia and plasmacytosis in lymph nodes of unimmunized animals, increased incidence of antibodies to self-antigens, and a heightened response to cross-linking of surface IgM. Statistically significant decreases in serum IgM and IgG3, but an increase in IgG1 and IgA were also observed. No lymphoid neoplasms have been identified in transgenic animals. The expansion of B cells in vivo is consistent with the overexpression of BCL3 as being one step in the multi-step process of leukemogenesis. The phenotype also suggests that BCL3 plays a part in B cell proliferation and isotype switching.

Full Text

Duke Authors

Cited Authors

  • Ong, ST; Hackbarth, ML; Degenstein, LC; Baunoch, DA; Anastasi, J; McKeithan, TW

Published Date

  • May 7, 1998

Published In

Volume / Issue

  • 16 / 18

Start / End Page

  • 2333 - 2343

PubMed ID

  • 9620550

Pubmed Central ID

  • 9620550

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1201771

Language

  • eng

Conference Location

  • England