Assays for measuring rivaroxaban: their suitability and limitations.

Published

Journal Article (Review)

Several new oral anticoagulants such as rivaroxaban (which targets Factor Xa) and dabigatran etexilate (which targets thrombin) are in advanced stages of clinical development and are already available for clinical use in some countries. Although these agents do not require routine coagulation monitoring, assays to assess the level of anticoagulation may be of assistance in certain circumstances such as in case of overdose, in patients with a hemorrhagic or thromboembolic event during treatment, or to assess compliance. Moreover, the influence of the new oral anticoagulants on routine coagulation tests must be recognized. The prothrombin time is not suitable for rivaroxaban measurement for several reasons, and the routinely used international normalized ratio for monitoring the vitamin K antagonists cannot be applied to rivaroxaban. Development of universal assays is challenging because the new oral anticoagulants have different targets, and even those with the same target have variable effects on routine coagulation assays. Focusing on rivaroxaban, there is emerging evidence that an anti-Factor Xa assay that uses rivaroxaban-containing plasma calibrators may provide the optimal method for determining plasma rivaroxaban concentrations.

Full Text

Duke Authors

Cited Authors

  • Lindhoff-Last, E; Samama, MM; Ortel, TL; Weitz, JI; Spiro, TE

Published Date

  • December 2010

Published In

Volume / Issue

  • 32 / 6

Start / End Page

  • 673 - 679

PubMed ID

  • 20844464

Pubmed Central ID

  • 20844464

Electronic International Standard Serial Number (EISSN)

  • 1536-3694

Digital Object Identifier (DOI)

  • 10.1097/FTD.0b013e3181f2f264

Language

  • eng

Conference Location

  • United States