Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHLBI/NIH guidelines.

Journal Article (Journal Article)

Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), the most common inherited bleeding disorder, affects males and females, and reflects deficiency or defects of VWF that may also cause decreased FVIII. It may also occur less commonly as an acquired disorder (acquired von Willebrand syndrome). This article briefly summarizes selected features of the March 2008 evidence-based clinical and laboratory diagnostic recommendations from the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel for assessment for VWD or other bleeding disorders or risks. Management of VWD is also addressed in the NHLBI guidelines, but is not summarized here. The VWD guidelines are available at the NHLBI Web site (

Full Text

Duke Authors

Cited Authors

  • Nichols, WL; Rick, ME; Ortel, TL; Montgomery, RR; Sadler, JE; Yawn, BP; James, AH; Hultin, MB; Manco-Johnson, MJ; Weinstein, M

Published Date

  • June 2009

Published In

Volume / Issue

  • 84 / 6

Start / End Page

  • 366 - 370

PubMed ID

  • 19415721

Pubmed Central ID

  • PMC5592788

Electronic International Standard Serial Number (EISSN)

  • 1096-8652

Digital Object Identifier (DOI)

  • 10.1002/ajh.21405


  • eng

Conference Location

  • United States