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Tissue factor in experimental acute lung injury

Publication ,  Journal Article
Welty-Wolf, KE; Carraway, MS; Idell, S; Ortel, TL; Ezban, M; Piantadosi, CA
Published in: Seminars in Hematology
January 1, 2001

Acute lung injury (ALI) is characterized by fibrin deposition in the tissue and vascular spaces. Coagulation is activated after exposure to endotoxin or bacteria, and a procoagulant environment rapidly develops in the vascular, interstitial, and alveolar spaces of the lung. These changes are tissue factor (TF)-dependent and associated with increases in inflammatory cytokines. Procoagulant changes also occur in the lungs of patients with the acute respiratory distress syndrome (ARDS), suggesting that epithelial inflammation activates the extrinsic pathway. Many inflammatory mediators have specific effects on coagulation; however, the role of TF in regulation of pulmonary inflammatory responses is less clear. Here we report initial data on blockade of TF-initiated coagulation in baboons with Escherichia coli sepsis-induced ALI, using active site-inactivated FVIIa (FVIIai ASIS). Treatment with FVIIai prevented plasma fibrinogen depletion and attenuated fibrin deposition in the tissues. The drug also decreased systemic cytokine responses and inflammatory changes in the lung, including neutrophil infiltration, and decreased edema. Coagulation blockade with FVIIai improved lung function by preserving gas exchange and compliance, decreased pulmonary hypertension, and enhanced renal function. These results show that TF-FVIIa complex is an important regulatory site for the pathologic response of the lung to sepsis. Copyright © 2001 by W.B. Saunders Company.

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Published In

Seminars in Hematology

DOI

ISSN

0037-1963

Publication Date

January 1, 2001

Volume

38

Issue

4 SUPPL. 12

Start / End Page

35 / 38

Related Subject Headings

  • Immunology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Welty-Wolf, K. E., Carraway, M. S., Idell, S., Ortel, T. L., Ezban, M., & Piantadosi, C. A. (2001). Tissue factor in experimental acute lung injury. Seminars in Hematology, 38(4 SUPPL. 12), 35–38. https://doi.org/10.1016/s0037-1963(01)90145-3
Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.” Seminars in Hematology 38, no. 4 SUPPL. 12 (January 1, 2001): 35–38. https://doi.org/10.1016/s0037-1963(01)90145-3.
Welty-Wolf KE, Carraway MS, Idell S, Ortel TL, Ezban M, Piantadosi CA. Tissue factor in experimental acute lung injury. Seminars in Hematology. 2001 Jan 1;38(4 SUPPL. 12):35–8.
Welty-Wolf, K. E., et al. “Tissue factor in experimental acute lung injury.” Seminars in Hematology, vol. 38, no. 4 SUPPL. 12, Jan. 2001, pp. 35–38. Scopus, doi:10.1016/s0037-1963(01)90145-3.
Welty-Wolf KE, Carraway MS, Idell S, Ortel TL, Ezban M, Piantadosi CA. Tissue factor in experimental acute lung injury. Seminars in Hematology. 2001 Jan 1;38(4 SUPPL. 12):35–38.
Journal cover image

Published In

Seminars in Hematology

DOI

ISSN

0037-1963

Publication Date

January 1, 2001

Volume

38

Issue

4 SUPPL. 12

Start / End Page

35 / 38

Related Subject Headings

  • Immunology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology