Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis.

Journal Article (Journal Article)

Sulforaphane (SUL), one of the isothiocyanates (ITCs), has recently been focused due to its inhibitory effects on tumor cell growth in vitro and in vivo, which is dependent on the direct effect on cancer cells. In the present study, we aimed to investigate the potential anti-angiogenic effect of SUL and its mechanism of action. Using the human umbilical vein endothelial cells (HUVECs) as a model of angiogenesis, we investigated the effect of SUL on the various steps of angiogenesis, including the proliferation of endothelial cells, tubular formation, and matrix metalloproteinase (MMP) production. Sulforaphane induced a dose-dependent decrease in the proliferative activity of endothelial cells, which was dependent on cell apoptosis. Also SUL inhibited tube formation on matrigel, but did not affect MMP production. The present results demonstrate the anti-angiogenic activity of SUL and its potential use as an anti-cancer drug is suggested.

Full Text

Duke Authors

Cited Authors

  • Asakage, M; Tsuno, NH; Kitayama, J; Tsuchiya, T; Yoneyama, S; Yamada, J; Okaji, Y; Kaisaki, S; Osada, T; Takahashi, K; Nagawa, H

Published Date

  • 2006

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 83 - 91

PubMed ID

  • 16821112

International Standard Serial Number (ISSN)

  • 0969-6970

Digital Object Identifier (DOI)

  • 10.1007/s10456-006-9034-0


  • eng

Conference Location

  • Germany