Dendritic cells activate antitumor immunity for malignant intracranial germ cell tumor: a case report.
Published
Journal Article
We report a 22-year-old male patient with a history of intracranial malignant germ cell tumor (GCT) who had undergone tumor resection twice, followed by radiation and chemotherapy. The tumor had rapidly recurred along the entire ventricular wall with extensive invasion into the brain parenchyma. The serum level of human beta-chorionic gonadotropin (beta-hCG) was 232.3 ng/ml on admission. Although tissue samples of the recurrent tumor could not be obtained, the previous histological diagnosis of germinoma and elevated serum beta-hCG levels suggested recurrence of malignant GCT. The patient declined chemotherapy but accepted dendritic cell (DC)-based immunotherapy. DC inoculation five times resulted in rapid tumor shrinkage and a significant decrease in the serum level of beta-hCG. Here we discuss the effectiveness of immunotherapy using DCs for recurrent intracranial malignant GCTs.
Full Text
Duke Authors
Cited Authors
- Osada, T; Fujimaki, T; Takamizawa, M; Tsuno, NH; Kirino, T; Shibata, Y
Published Date
- August 2001
Published In
Volume / Issue
- 31 / 8
Start / End Page
- 403 - 406
PubMed ID
- 11574635
Pubmed Central ID
- 11574635
International Standard Serial Number (ISSN)
- 0368-2811
Digital Object Identifier (DOI)
- 10.1093/jjco/hye076
Language
- eng
Conference Location
- England