Dendritic cells activate antitumor immunity for malignant intracranial germ cell tumor: a case report.


Journal Article

We report a 22-year-old male patient with a history of intracranial malignant germ cell tumor (GCT) who had undergone tumor resection twice, followed by radiation and chemotherapy. The tumor had rapidly recurred along the entire ventricular wall with extensive invasion into the brain parenchyma. The serum level of human beta-chorionic gonadotropin (beta-hCG) was 232.3 ng/ml on admission. Although tissue samples of the recurrent tumor could not be obtained, the previous histological diagnosis of germinoma and elevated serum beta-hCG levels suggested recurrence of malignant GCT. The patient declined chemotherapy but accepted dendritic cell (DC)-based immunotherapy. DC inoculation five times resulted in rapid tumor shrinkage and a significant decrease in the serum level of beta-hCG. Here we discuss the effectiveness of immunotherapy using DCs for recurrent intracranial malignant GCTs.

Full Text

Duke Authors

Cited Authors

  • Osada, T; Fujimaki, T; Takamizawa, M; Tsuno, NH; Kirino, T; Shibata, Y

Published Date

  • August 2001

Published In

Volume / Issue

  • 31 / 8

Start / End Page

  • 403 - 406

PubMed ID

  • 11574635

Pubmed Central ID

  • 11574635

International Standard Serial Number (ISSN)

  • 0368-2811

Digital Object Identifier (DOI)

  • 10.1093/jjco/hye076


  • eng

Conference Location

  • England