CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.
Published
Journal Article
A unique subset of T cells that co-express NKR-P1, which is a lectin type of NK receptor and is thought to have a major role in triggering NK activity, has been identified. In mice, NK1.1 (mouse NKR-P1C)(+) T cells, called NKT cells, preferentially accumulate in the liver and bone marrow. They predominantly use invariant Valpha14 chain TCR and phenotypically are CD4(+)CD8(-) or CD4(-)CD8(-) T cells. In this study, we analyzed, phenotypically and functionally, the NKR-P1A (analogue of murine NKR-P1C)(+) T cells resident in the human liver. Here, we show that in complete contrast to the NKT cells in the mouse liver, the majority of NKR-P1A(+) T cells in the human liver are CD8(+) and their TCR repertoire is not skewed to Valpha24 TCR, the homologue of murine Valpha14 TCR. Almost all of the NKR-P1A(+) T cells in the human liver expressed CD69, suggesting that they were activated. Furthermore, the NKR-P1A(+) T cells in the human liver exhibited strong cytotoxicity against a variety of tumor cell lines including K562, Molt4 and some colonic adenocarcinoma cell lines.
Full Text
Duke Authors
Cited Authors
- Ishihara, S; Nieda, M; Kitayama, J; Osada, T; Yabe, T; Ishikawa, Y; Nagawa, H; Muto, T; Juji, T
Published Date
- August 1999
Published In
Volume / Issue
- 29 / 8
Start / End Page
- 2406 - 2413
PubMed ID
- 10458753
Pubmed Central ID
- 10458753
International Standard Serial Number (ISSN)
- 0014-2980
Digital Object Identifier (DOI)
- 10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F
Language
- eng
Conference Location
- Germany