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CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.

Publication ,  Journal Article
Ishihara, S; Nieda, M; Kitayama, J; Osada, T; Yabe, T; Ishikawa, Y; Nagawa, H; Muto, T; Juji, T
Published in: Eur J Immunol
August 1999

A unique subset of T cells that co-express NKR-P1, which is a lectin type of NK receptor and is thought to have a major role in triggering NK activity, has been identified. In mice, NK1.1 (mouse NKR-P1C)(+) T cells, called NKT cells, preferentially accumulate in the liver and bone marrow. They predominantly use invariant Valpha14 chain TCR and phenotypically are CD4(+)CD8(-) or CD4(-)CD8(-) T cells. In this study, we analyzed, phenotypically and functionally, the NKR-P1A (analogue of murine NKR-P1C)(+) T cells resident in the human liver. Here, we show that in complete contrast to the NKT cells in the mouse liver, the majority of NKR-P1A(+) T cells in the human liver are CD8(+) and their TCR repertoire is not skewed to Valpha24 TCR, the homologue of murine Valpha14 TCR. Almost all of the NKR-P1A(+) T cells in the human liver expressed CD69, suggesting that they were activated. Furthermore, the NKR-P1A(+) T cells in the human liver exhibited strong cytotoxicity against a variety of tumor cell lines including K562, Molt4 and some colonic adenocarcinoma cell lines.

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Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

August 1999

Volume

29

Issue

8

Start / End Page

2406 / 2413

Location

Germany

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocyte Subsets
  • Receptors, Immunologic
  • NK Cell Lectin-Like Receptor Subfamily B
  • Mice
  • Liver
  • Lectins, C-Type
  • Killer Cells, Natural
  • In Vitro Techniques
  • Immunology
 

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Ishihara, S., Nieda, M., Kitayama, J., Osada, T., Yabe, T., Ishikawa, Y., … Juji, T. (1999). CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. Eur J Immunol, 29(8), 2406–2413. https://doi.org/10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F
Ishihara, S., M. Nieda, J. Kitayama, T. Osada, T. Yabe, Y. Ishikawa, H. Nagawa, T. Muto, and T. Juji. “CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.Eur J Immunol 29, no. 8 (August 1999): 2406–13. https://doi.org/10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F.
Ishihara S, Nieda M, Kitayama J, Osada T, Yabe T, Ishikawa Y, et al. CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. Eur J Immunol. 1999 Aug;29(8):2406–13.
Ishihara, S., et al. “CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.Eur J Immunol, vol. 29, no. 8, Aug. 1999, pp. 2406–13. Pubmed, doi:10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F.
Ishihara S, Nieda M, Kitayama J, Osada T, Yabe T, Ishikawa Y, Nagawa H, Muto T, Juji T. CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. Eur J Immunol. 1999 Aug;29(8):2406–2413.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

August 1999

Volume

29

Issue

8

Start / End Page

2406 / 2413

Location

Germany

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocyte Subsets
  • Receptors, Immunologic
  • NK Cell Lectin-Like Receptor Subfamily B
  • Mice
  • Liver
  • Lectins, C-Type
  • Killer Cells, Natural
  • In Vitro Techniques
  • Immunology