CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.

Journal Article (Journal Article)

A unique subset of T cells that co-express NKR-P1, which is a lectin type of NK receptor and is thought to have a major role in triggering NK activity, has been identified. In mice, NK1.1 (mouse NKR-P1C)(+) T cells, called NKT cells, preferentially accumulate in the liver and bone marrow. They predominantly use invariant Valpha14 chain TCR and phenotypically are CD4(+)CD8(-) or CD4(-)CD8(-) T cells. In this study, we analyzed, phenotypically and functionally, the NKR-P1A (analogue of murine NKR-P1C)(+) T cells resident in the human liver. Here, we show that in complete contrast to the NKT cells in the mouse liver, the majority of NKR-P1A(+) T cells in the human liver are CD8(+) and their TCR repertoire is not skewed to Valpha24 TCR, the homologue of murine Valpha14 TCR. Almost all of the NKR-P1A(+) T cells in the human liver expressed CD69, suggesting that they were activated. Furthermore, the NKR-P1A(+) T cells in the human liver exhibited strong cytotoxicity against a variety of tumor cell lines including K562, Molt4 and some colonic adenocarcinoma cell lines.

Full Text

Duke Authors

Cited Authors

  • Ishihara, S; Nieda, M; Kitayama, J; Osada, T; Yabe, T; Ishikawa, Y; Nagawa, H; Muto, T; Juji, T

Published Date

  • August 1999

Published In

Volume / Issue

  • 29 / 8

Start / End Page

  • 2406 - 2413

PubMed ID

  • 10458753

Pubmed Central ID

  • 10458753

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F


  • eng

Conference Location

  • Germany